4,4'-Dimethoxytrityl chloride
Synonym(s):4,4′-Dimethoxytrityl chloride;Chloro-4,4′-dimethoxytriphenylmethane;DMT;DMT-Cl
- CAS NO.：40615-36-9
- Empirical Formula: C21H19ClO2
- Molecular Weight: 338.83
- MDL number: MFCD00008409
- EINECS: 255-002-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 4,4'-Dimethoxytrityl chloride?
Chemical properties
4,4'-Dimethoxytrityl chloride is pink powder
The Uses of 4,4'-Dimethoxytrityl chloride
4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis
The Uses of 4,4'-Dimethoxytrityl chloride
Hydroxyl protecting group for nucleosides and nucleotides.
The Uses of 4,4'-Dimethoxytrityl chloride
4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.
Flammability and Explosibility
Not classified
Purification Methods
DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.]
Properties of 4,4'-Dimethoxytrityl chloride
| Melting point: | 123-125 °C |
| Boiling point: | 455.07°C (rough estimate) |
| Density | 1.0887 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5330 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| color | Pink |
| Water Solubility | Soluble in chloroform and methanol. Partially soluble in water |
| Sensitive | Moisture Sensitive |
| BRN | 2471942 |
| Stability: | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 40615-36-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9) |
Safety information for 4,4'-Dimethoxytrityl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H317:Sensitisation, Skin H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,4'-Dimethoxytrityl chloride
| InChIKey | JBWYRBLDOOOJEU-UHFFFAOYSA-N |
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