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HomeProduct name list4,4'-Dimethoxytrityl chloride

4,4'-Dimethoxytrityl chloride

Synonym(s):4,4′-Dimethoxytrityl chloride;Chloro-4,4′-dimethoxytriphenylmethane;DMT;DMT-Cl

  • CAS NO.:40615-36-9
  • Empirical Formula: C21H19ClO2
  • Molecular Weight: 338.83
  • MDL number: MFCD00008409
  • EINECS: 255-002-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-17 18:24:26
4,4'-Dimethoxytrityl chloride Structural

What is 4,4'-Dimethoxytrityl chloride?

Chemical properties

4,4'-Dimethoxytrityl chloride is pink powder

The Uses of 4,4'-Dimethoxytrityl chloride

4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.

The Uses of 4,4'-Dimethoxytrityl chloride

4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis

The Uses of 4,4'-Dimethoxytrityl chloride

Hydroxyl protecting group for nucleosides and nucleotides.

Flammability and Explosibility

Not classified

Purification Methods

DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.]

Properties of 4,4'-Dimethoxytrityl chloride

Melting point: 123-125 °C
Boiling point: 455.07°C (rough estimate)
Density  1.0887 (rough estimate)
vapor pressure  0Pa at 20℃
refractive index  1.5330 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Powder
color  Pink
Water Solubility  Soluble in chloroform and methanol. Partially soluble in water
Sensitive  Moisture Sensitive
BRN  2471942
Stability: Hygroscopic, Moisture Sensitive
CAS DataBase Reference 40615-36-9(CAS DataBase Reference)
NIST Chemistry Reference Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9)

Safety information for 4,4'-Dimethoxytrityl chloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H314:Skin corrosion/irritation
H317:Sensitisation, Skin
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4,4'-Dimethoxytrityl chloride

InChIKey JBWYRBLDOOOJEU-UHFFFAOYSA-N

4,4'-Dimethoxytrityl chloride manufacturer

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