4,4'-Dimethoxytrityl chloride
Synonym(s):4,4′-Dimethoxytrityl chloride;Chloro-4,4′-dimethoxytriphenylmethane;DMT;DMT-Cl
- CAS NO.：40615-36-9
- Empirical Formula: C21H19ClO2
- Molecular Weight: 338.83
- MDL number: MFCD00008409
- EINECS: 255-002-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is 4,4'-Dimethoxytrityl chloride?
Chemical properties
4,4'-Dimethoxytrityl chloride is pink powder
The Uses of 4,4'-Dimethoxytrityl chloride
4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.
The Uses of 4,4'-Dimethoxytrityl chloride
4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis
The Uses of 4,4'-Dimethoxytrityl chloride
Hydroxyl protecting group for nucleosides and nucleotides.
Flammability and Explosibility
Not classified
Purification Methods
DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.]
Properties of 4,4'-Dimethoxytrityl chloride
| Melting point: | 123-125 °C |
| Boiling point: | 455.07°C (rough estimate) |
| Density | 1.0887 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5330 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| color | Pink |
| Water Solubility | Soluble in chloroform and methanol. Partially soluble in water |
| Sensitive | Moisture Sensitive |
| BRN | 2471942 |
| Stability: | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 40615-36-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9) |
Safety information for 4,4'-Dimethoxytrityl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H317:Sensitisation, Skin H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,4'-Dimethoxytrityl chloride
| InChIKey | JBWYRBLDOOOJEU-UHFFFAOYSA-N |
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