4,4-Diethoxy-N,N-dimethyl-1-butanamine
Synonym(s):N,N-Dimethyl-4-aminobutanal diethyl acetal;1-(N,N-Dimethylamino)-4,4-diethoxybutane;4,4-Diethoxy-N,N-dimethyl-1-butanamine;4,4-Diethoxy-N,N-dimethylbutanamine;4,4-Diethoxy-N,N-dimethylbutylamine
- CAS NO.：1116-77-4
- Empirical Formula: C10H23NO2
- Molecular Weight: 189.3
- MDL number: MFCD00671479
- EINECS: 601-109-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-25 16:21:11
What is 4,4-Diethoxy-N,N-dimethyl-1-butanamine?
Chemical properties
Light yellow liquid
The Uses of 4,4-Diethoxy-N,N-dimethyl-1-butanamine
4,4-Diethoxy-N,N-dimethyl-1-butanamine is used in organic synthesis and pharmaceutical intermediates, it is an intermediate for Sumatriptan, Rizatriptan, Almotriptan, Zolmitriptan.
What are the applications of Application
4-Dimethylaminobutyraldehyde Diethyl Acetal (Zolmitriptan USP Related Compound H) is used in the preparation of N,N-Dimethyltryptamines, 5-HT1D receptor agonists, for medicinal treatments such as antimigraine drugs.
Preparation
4-Dimethylaminobutyraldehyde diethyl acetal synthesis: The reaction of 1-bromo-3-chloro propane and dimethylamine solution with PEG as a phase transfer catalyst, and obtained 3-dimethylamino-1-chloro propane. 3-dimethylamino-1-chloro propane reacted with magnesium and Grinard reagent was acquired. 4-Dimethylaminobutyraldehyde diethyl acetal is obtained by the reaction of Grinard reagent and triethyl orthoformate. The yield was 70.11%.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 2401, 1994 DOI: 10.1016/0040-4039(94)85230-8
Properties of 4,4-Diethoxy-N,N-dimethyl-1-butanamine
| Boiling point: | 194-195C |
| Density | 0.844 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 158 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate |
| form | Oil |
| pka | 9.71±0.28(Predicted) |
| color | Colourless to Pale Yellow |
| CAS DataBase Reference | 1116-77-4(CAS DataBase Reference) |
Safety information for 4,4-Diethoxy-N,N-dimethyl-1-butanamine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4,4-Diethoxy-N,N-dimethyl-1-butanamine
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