4-TRIMETHYLSILYL-3-BUTYN-2-OL
- CAS NO.:6999-19-5
- Empirical Formula: C7H14OSi
- Molecular Weight: 142.27
- MDL number: MFCD00190213
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-TRIMETHYLSILYL-3-BUTYN-2-OL?
Chemical properties
Colorless liquid
Physical properties
bp 83–85°C (13 mmHg).
The Uses of 4-TRIMETHYLSILYL-3-BUTYN-2-OL
More recently, Mulzer has reported use of the corresponding allenylsilane derived from 4-TMS-3-butyn-2-ol for use in the synthesis of the C13–C18 fragment of branimycin (eq 2).
Preparation
racemic 4-trimethylsilyl-3-butyn-2-ol can
be prepared by deprotonation with strong bases (BuLi, LDA,
Grignards reagents) of trimethylsilylacetylene followed
by addition to acetaldehyde.Deprotonation of 3-butyn-2-
ol followed by quenching with excess trimethylsilyl chloride
followed by concomitant hydrolysis of the trimethylsilyl ether
is generally the most straightforward route.Enzymatic reduction
of 4-TMS-3-butyn-2-one has also been used to prepare the
reagent using alcohol dehydrogenase.
Preparation of nonracemic 4-TMS-3-butyn-2-ol has been
accomplished by asymmetric addition of dimethylzinc to
acetaldehyde promoted by TADDOL or addition of a
trimethylsilylvinylsulfoxide to acetaldehyde followed by thermal
elimination of the sulfoxide.Asymmetric reduction of 4-
TMS-3-butyn-2-one using stoichiometric reducing reagents,
catalytic transfer hydrodrogenation,and enzymatic reduction
with isolated protein or whole cells afford the 4-TMS-3-butyn-
2-ol with varying degrees of enantioenrichment.Enzymatic resolution by esterification of the racemic alcohol is the method
of choice for the large-scale preparation.
Properties of 4-TRIMETHYLSILYL-3-BUTYN-2-OL
Boiling point: | 76 °C |
Density | 0.847 g/mL at 25 °C |
refractive index | n |
Flash point: | 143 °F |
storage temp. | 2-8°C |
solubility | highly soluble in all standard organic solvents
(hexanes, toluene, CH2Cl2, EtOAc, alcohols, ethers). Partially
soluble in water. |
form | clear liquid |
pka | 13.78±0.20(Predicted) |
Specific Gravity | 0.846 |
color | Colorless to Light orange to Yellow |
Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
BRN | 1923632 |
CAS DataBase Reference | 6999-19-5(CAS DataBase Reference) |
Safety information for 4-TRIMETHYLSILYL-3-BUTYN-2-OL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-TRIMETHYLSILYL-3-BUTYN-2-OL
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