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HomeProduct name list4-(pyridine-2-yl) pyrimidin-2-amine

4-(pyridine-2-yl) pyrimidin-2-amine

  • CAS NO.:66521-65-1
  • Empirical Formula: C9H8N4
  • Molecular Weight: 172.19
  • MDL number: MFCD00138711
  • EINECS: 604-604-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
4-(pyridine-2-yl) pyrimidin-2-amine Structural

What is 4-(pyridine-2-yl) pyrimidin-2-amine?

Chemical properties

Off-White Solid

The Uses of 4-(pyridine-2-yl) pyrimidin-2-amine

Intermediate in the preparation of Nilotinib.

Preparation

Synthesis of 4-(pyridine-2-yl) pyrimidin-2-amine (P2P). (0.5 g, 2.84 mmol) of (Z)-3- dimethylamino-1-(pyridine-2-yl)prop-2-en-1-one was suspended was suspended in 15ml of nbutanol. To the solution (0.346 g, 2.84 mmol) of guanidine nitrate added and followed by the addition of NaOH(0.114 g, 2.84 mmol) and reflux this mixture at 110℃ for 12h. After completion of the reaction the mixture was filtered, the clear yellow solution of filtrate kept for room temperature. After 20 min yellow crystal formed and dried in a vacuum under reduced pressure. Yield (0.296 g, 60%) IR (KBr): 3471, 3142, 1622, 1568, 1463, 1340, 1215, 1095, 993, 783, 650, 524.1H NMR (300 MHz, CDCl3) δ 8.69 (dd, J = 11.9, 10.0 Hz, 1H), 8.45 (dd, J = 5.1, 2.6 Hz, 1H), 8.40 – 8.20 (m, 1H), 7.85 (ddd, J = 17.9, 9.4, 7.3 Hz, 1H), 7.64 (dd, J = 5.1, 2.8 Hz, 1H), 7.53 – 7.30 (m, 1H), 5.30 (s, 2H). 13C NMR (75 MHz, CDCl3) δ 164.49 (s), 163.75 (s), 159.65 (s), 154.75 (s), 149.79 (s), 137.29 (s), 125.41 (s), 121.87 (s), 108.26 (s).

Properties of 4-(pyridine-2-yl) pyrimidin-2-amine

Melting point: 137-139°C
Boiling point: 426.5±37.0 °C(Predicted)
Density  1.259±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 3.34±0.10(Predicted)
color  Off-White to Pale Yellow

Safety information for 4-(pyridine-2-yl) pyrimidin-2-amine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-(pyridine-2-yl) pyrimidin-2-amine

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