4-Phenylbutanol
- CAS NO.:3360-41-6
- Empirical Formula: C10H14O
- Molecular Weight: 150.22
- MDL number: MFCD00002971
- EINECS: 222-128-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is 4-Phenylbutanol?
Chemical properties
colourless liquid
The Uses of 4-Phenylbutanol
4-Phenyl-1-butanol is used as a reagent in the synthesis of substituted pyrrolidine-2-carboxylic acids which are used in the treatment of AT2 receptor function associated diseases.
The Uses of 4-Phenylbutanol
4-Phenyl-1-butanol was used in synthesis of NK105, a paclitaxel-incorporating micellar nanoparticle formulation.
Production Methods
4-Phenylbutanol can be produced 1) from Phenylacetaldehyde and Acetaldehyde by condensation, followed by hydrogenation and reduction of the unsaturated aldehyde. 2) from Phenylethyl magnesiumbromide plus Ethylene oxide in a Grignard type reaction.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 31, p. 2607, 1983 DOI: 10.1248/cpb.31.2607
Journal of the American Chemical Society, 73, p. 124, 1951 DOI: 10.1021/ja01145a045
General Description
4-Phenyl-1-butanol is oxidized by ceric ammonium nitrate in acetonitrile to afford 2-phenyltetrahydrofuran. It undergoes cyclization in presence of phosphoric acid at high temperature to yield tetralin.
Properties of 4-Phenylbutanol
Boiling point: | 140-142 °C14 mm Hg(lit.) |
Density | 0.984 g/mL at 20 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform |
form | Liquid |
pka | 15.13±0.10(Predicted) |
color | Clear colorless |
Odor | Sweet, but rather heavy, herbaceous-rosy odor |
BRN | 2042122 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 3360-41-6(CAS DataBase Reference) |
NIST Chemistry Reference | Benzenebutanol(3360-41-6) |
EPA Substance Registry System | Benzenebutanol (3360-41-6) |
Safety information for 4-Phenylbutanol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-Phenylbutanol
InChIKey | LDZLXQFDGRCELX-UHFFFAOYSA-N |
Abamectin manufacturer
Alchem Synthon Pvt Ltd
Sam Fine O Chem Limited
Khagga Life Sciences
Shree Vinayaka Life Sciences Pvt., Ltd.
Pratap Organics Pvt Ltd
Horizon Chemicals
Tosco Pharmachem Pvt Ltd
Jayco Chemical Industries
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