4-Phenylbutanol

CAS NO.：3360-41-6
Empirical Formula: C10H14O
Molecular Weight: 150.22
MDL number: MFCD00002971
EINECS: 222-128-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is 4-Phenylbutanol?

Chemical properties

colourless liquid

The Uses of 4-Phenylbutanol

4-Phenyl-1-butanol was used in synthesis of NK105, a paclitaxel-incorporating micellar nanoparticle formulation.

The Uses of 4-Phenylbutanol

4-Phenyl-1-butanol is used as a reagent in the synthesis of substituted pyrrolidine-2-carboxylic acids which are used in the treatment of AT2 receptor function associated diseases.

Production Methods

4-Phenylbutanol can be produced 1) from Phenylacetaldehyde and Acetaldehyde by condensation, followed by hydrogenation and reduction of the unsaturated aldehyde. 2) from Phenylethyl magnesiumbromide plus Ethylene oxide in a Grignard type reaction.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 31, p. 2607, 1983 DOI: 10.1248/cpb.31.2607
Journal of the American Chemical Society, 73, p. 124, 1951 DOI: 10.1021/ja01145a045

General Description

4-Phenyl-1-butanol is oxidized by ceric ammonium nitrate in acetonitrile to afford 2-phenyltetrahydrofuran. It undergoes cyclization in presence of phosphoric acid at high temperature to yield tetralin.

Properties of 4-Phenylbutanol

Boiling point:	140-142 °C14 mm Hg(lit.)
Density	0.984 g/mL at 20 °C(lit.)
refractive index	n20/D 1.521(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform
form	Liquid
pka	15.13±0.10(Predicted)
color	Clear colorless
Odor	Sweet, but rather heavy, herbaceous-rosy odor
BRN	2042122
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	3360-41-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzenebutanol(3360-41-6)
EPA Substance Registry System	Benzenebutanol (3360-41-6)

Safety information for 4-Phenylbutanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.