4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
Synonym(s):4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester;GGTI-2147 - CAS 191102-87-1 - Calbiochem
- CAS NO.:191102-87-1
- Empirical Formula: C28H30N4O3
- Molecular Weight: 470.56
- MDL number: MFCD22581512
- Update Date: 2023-07-14 17:49:10
What is 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER?
The Uses of 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.
What are the applications of Application
GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A
Properties of 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
Boiling point: | 710.6±60.0 °C(Predicted) |
Density | 1.224±0.06 g/cm3(Predicted) |
solubility | Soluble in DMSO |
pka | 13.22±0.46(Predicted) |
form | Solid |
Sensitive | Light Sensitive & Hygroscopic |
Safety information for 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
Computed Descriptors for 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
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