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HomeProduct name list4'-Methylthioacetophenone

4'-Methylthioacetophenone

  • CAS NO.:1778-09-2
  • Empirical Formula: C9H10OS
  • Molecular Weight: 166.24
  • MDL number: MFCD00039835
  • EINECS: 217-213-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
4'-Methylthioacetophenone Structural

What is 4'-Methylthioacetophenone?

Chemical properties

White to light yellow crystal powde

The Uses of 4'-Methylthioacetophenone

4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2857, 1951 DOI: 10.1021/ja01150a127
The Journal of Organic Chemistry, 56, p. 5955, 1991 DOI: 10.1021/jo00020a048

General Description

4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

Properties of 4'-Methylthioacetophenone

Melting point: 80-82 °C(lit.)
Boiling point: 135 °C
Density  1.1369 (rough estimate)
refractive index  1.5600 (estimate)
Flash point: 135°C/1mm
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform, Methanol
form  Solid
color  White to Off-White
BRN  1860517
CAS DataBase Reference 1778-09-2(CAS DataBase Reference)
NIST Chemistry Reference 4-CH3S-C6H4-COCH3(1778-09-2)
EPA Substance Registry System 4'-(Methylmercapto)acetophenone (1778-09-2)

Safety information for 4'-Methylthioacetophenone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4'-Methylthioacetophenone

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