4-(Difluoromethoxy)nitrobenzene
- CAS NO.：1544-86-1
- Empirical Formula: C7H5F2NO3
- Molecular Weight: 189.12
- MDL number: MFCD00085009
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-(Difluoromethoxy)nitrobenzene?
Chemical properties
Pale Yellow Crystal.
The Uses of 4-(Difluoromethoxy)nitrobenzene
4-(Difluoromethoxy)nitrobenzene is an industrial chemical that can be used to make 4-fluoro-3-pyridinol (F3P), a compound that has potential as a new drug for the treatment of cancer. The synthesis of F3P begins with the reaction of 4-(difluoromethoxy)nitrobenzene and potassium hydroxide in methanol, which yields 4-fluoro-3-hydroxypyridine. This product is then reacted with ammonia gas and pyridine to yield F3P. The final step involves heating the product at high temperature with nitric acid, which yields nitrobenztriazole.
General Description
4-(Difluoromethoxy)nitrobenzene (1-(difluoromethoxy)-4-nitrobenzene) can be synthesized by reacting 4-nitrophenol with KOH, water and methanol.
Properties of 4-(Difluoromethoxy)nitrobenzene
| Melting point: | 37-40 °C (lit.) |
| Boiling point: | 108 °C |
| Density | 1.384±0.06 g/cm3(Predicted) |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| form | powder to lump |
| color | Light yellow to Brown to Dark green |
| FreezingPoint | 31.0 to 34.0 ℃ |
| CAS DataBase Reference | 1544-86-1(CAS DataBase Reference) |
Safety information for 4-(Difluoromethoxy)nitrobenzene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-(Difluoromethoxy)nitrobenzene
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