4-Chloro-7-azaindole

Synonym(s):4-Chloro-1H-pyrrolo[2,3-b]pyridine

CAS NO.：55052-28-3
Empirical Formula: C7H5ClN2
Molecular Weight: 152.58
MDL number: MFCD08272232
EINECS: 626-806-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-27 17:30:52

What is 4-Chloro-7-azaindole?

Description

4-Chloro-7-azaindole belongs to the class of azaindole compounds, which has anticancer, antibacterial, antiviral and other biological activities. 4-Chloro-7-azaindole is mainly used as an organic intermediate in the preparation of 7-azaindole derivatives, GDC-0575, and Janus kinase inhibitors.

Chemical properties

White to brown solid

The Uses of 4-Chloro-7-azaindole

4-Chloro-7-azaindole can be used as a useful intermediate for drug discovery research.

The Uses of 4-Chloro-7-azaindole

A useful intermediate for drug discovery research such as used in the synthesis of 7-azaindole derivatives, synthetic cytokinin analogues.

Synthesis Reference(s)

The Journal of Organic Chemistry, 71, p. 4021, 2006 DOI: 10.1021/jo0602571

Properties of 4-Chloro-7-azaindole

Melting point:	176-181 °C
Density	1.425±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.98±0.40(Predicted)
color	Light yellow to brown
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C7H5ClN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)
CAS DataBase Reference	55052-28-3(CAS DataBase Reference)

Safety information for 4-Chloro-7-azaindole

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.