4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE

CAS NO.：84905-80-6
Empirical Formula: C6H4ClN3
Molecular Weight: 153.57
MDL number: MFCD06658411
EINECS: 632-937-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-27 16:27:43

What is 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE?

Description

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is a purine analog that inhibits the growth of bacteria by binding to the enzyme DNA gyrase. It has been shown to be effective against staphylococcus and Mycobacterium tuberculosis.

The Uses of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is a chlorinated pyrrolopyrimidine used in the preparation of compounds with antibacterial and antitumor activities.

What are the applications of Application

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine binds to the enzyme DNA gyrase and prevents it from breaking down the bacterial DNA. This drug also has antimycobacterial activity due to its ability to bind to the enzyme RNA polymerase.

Properties of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE

Melting point:	186-188 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
Boiling point:	325.9±22.0 °C(Predicted)
Density	1.531±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	11.58±0.40(Predicted)
color	Off-white

Safety information for 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.