4-CHLORO-2-NITROPHENOL
- CAS NO.：89-64-5
- Empirical Formula: C6H4ClNO3
- Molecular Weight: 173.55
- MDL number: MFCD00007113
- EINECS: 201-927-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-21 11:03:52
What is 4-CHLORO-2-NITROPHENOL?
Chemical properties
yellow powder
The Uses of 4-CHLORO-2-NITROPHENOL
Reduction of 4-Chloro-2-nitrophenol gives 2-amino-4- chlorophenol [95-85-2], and chlorination yields 2,4-dichloro-6-nitrophenol [609-89-2], which is reduced to 2-amino-4,6-dichlorophenol [527-62-8]. These substituted aminophenols are members of a large class of diazo components used for hydroxyazo dyes, which are important for wool and polyamide when converted to their chromium complexes. For the amine derived from the methyl ether of 4-Chloro-2-nitrophenol, 4- chloro-o-anisidine [93-50-5], the preferred route is methoxylation of 2,5-dichloronitrobenzene followed by reduction. 2-amino-4-chlorophenol reacts with phosgene to give 5- chlorobenzoxolinone which nitrates to the 6-nitro compound; the latter undergoes alkaline hydrolysis to 2-amino-4- chloro-5-nitrophenol.
Production Methods
2,5-Dichloronitrobenzene is hydrolyzed with 8 % aqueous sodium hydroxide at 120 – 130 ℃ under pressure.
Properties of 4-CHLORO-2-NITROPHENOL
| Melting point: | 85-87 °C(lit.) |
| Boiling point: | 242.5±20.0 °C(Predicted) |
| Density | 1.4914 (rough estimate) |
| refractive index | 1.5810 (estimate) |
| solubility | dioxane: soluble0.5g/5mL, clear, faintly yellow to yellow |
| pka | pK1: 6.48 (25°C) |
| form | powder to crystal |
| color | Light yellow to Yellow to Orange |
| BRN | 2048031 |
| CAS DataBase Reference | 89-64-5(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Chloro-2-nitrophenol (89-64-5) |
Safety information for 4-CHLORO-2-NITROPHENOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-CHLORO-2-NITROPHENOL
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin M Tubulysin D Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin H 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 4-Bromo-N,N-bis(4-iodophenyl)aniline Methyl 4-amino-3-(piperidin-1-yl)benzoate 5-Aminophthalazine 2-Ethoxy-4-nitrobenzoic acid Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 4-bromo-2,5-difluoro benzoic acid 4-fluoro-1-methyl-pyrazoleRelated products of tetrahydrofuran
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