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HomeProduct name list4-CHLORO-1-NAPHTHOL

4-CHLORO-1-NAPHTHOL

Synonym(s):4-chloronaphthalen-1-ol;4-CN

  • CAS NO.:604-44-4
  • Empirical Formula: C10H7ClO
  • Molecular Weight: 178.62
  • MDL number: MFCD00003974
  • EINECS: 210-068-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:57
4-CHLORO-1-NAPHTHOL Structural

What is 4-CHLORO-1-NAPHTHOL?

Chemical properties

Off white to tan crystals

The Uses of 4-CHLORO-1-NAPHTHOL

4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method.

The Uses of 4-CHLORO-1-NAPHTHOL

Suitable for visualizing protein-peroxidase conjugates in western blotting.

What are the applications of Application

4-Chloro-1-naphthol is a chromogenic peroxidase substrate enzyme-linked detection procedures

Synthesis Reference(s)

Tetrahedron, 38, p. 2347, 1982 DOI: 10.1016/0040-4020(82)87012-9

General Description

4-Chloro-1-naphthol is primarily used for the detection of proteins, it gives a characteristic purple precipitate and the reactions are easily controllable. It can be used as a substitute for benzidine compounds, which are considered to be carcinogenic.

Biochem/physiol Actions

4-Chloro-1-naphthol serves as a substrate for horseradish peroxidase.

Purification Methods

Crystallise the naphthol from EtOH or CHCl3. [Beilstein 6 H 611, 6 II 582, 6 III 2933, 6 IV 4233.]

Properties of 4-CHLORO-1-NAPHTHOL

Melting point: 118-121 °C(lit.)
Boiling point: 254.41°C (rough estimate)
Density  密度
refractive index  1.4575 (estimate)
Flash point: 73 °C
storage temp.  -20°C
solubility  methanol: 50 mg/mL, clear, colorless to very faintly yellow
form  tablets (~32 mg each)
pka 9.11±0.40(Predicted)
color  Off-white to gray to light brown
BRN  509750
CAS DataBase Reference 604-44-4(CAS DataBase Reference)
EPA Substance Registry System 1-Naphthalenol, 4-chloro- (604-44-4)

Safety information for 4-CHLORO-1-NAPHTHOL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 4-CHLORO-1-NAPHTHOL

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