4-BROMO-TETRAHYDROPYRAN

Synonym(s):4-Bromooxacyclohexane;4-Bromotetrahydro-2H-pyran

Light yellow liquid

4-Bromo-tetrahydropyran is a useful reactant in organic synthesis.

Reactant for:

Nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents
Preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans
Preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes
Preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity
Preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives
Synthesis of gephyrotoxin via the Schmidt reaction

Boiling point:	178℃
Density	1.467 g/cm3 at 25 °C
refractive index	n20/D1.497
Flash point:	69℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	clear liquid
color	Colorless to Yellow to Orange
CAS DataBase Reference	25637-16-5

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.