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HomeProduct name list4-Aminobenzohydrazide

4-Aminobenzohydrazide

Synonym(s):Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem

  • CAS NO.:5351-17-7
  • Empirical Formula: C7H9N3O
  • Molecular Weight: 151.17
  • MDL number: MFCD00007606
  • EINECS: 226-324-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-11 14:41:12
4-Aminobenzohydrazide Structural

What is 4-Aminobenzohydrazide?

Description

4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 μM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils with IC50 values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.

Chemical properties

White or beige crystals or powder

The Uses of 4-Aminobenzohydrazide

4-Aminobenzhydrazide has an important role in the peroxidation activity of MPO. It is also used in enzyme preparations and in cell cultures.

The Uses of 4-Aminobenzohydrazide

4-Aminobenzoic hydrazide can be used as a reactant to synthesize:

  • Acylhydrazone Schiff base ligand by condensation reaction with 2-acetylpyridine.
  • Oligomeric transition metal complexes applicable in the fabrication of organic-inorganic hybrid devices with efficient electrical and photoelectrical properties.
  • Oxovanadium(IV)-hydrazide complex as a potential radical scavenger.

What are the applications of Application

Myeloperoxidase Inhibitor-I is an irreversible and specific inhibitor of the peroxidation activity of MPO

Properties of 4-Aminobenzohydrazide

Melting point: 225-227 °C (lit.)
Boiling point: 273.17°C (rough estimate)
Density  1.2100 (rough estimate)
refractive index  1.5860 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
pka 13.05±0.10(Predicted)
form  Crystals or Powder
color  White or beige
Water Solubility  Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible).
BRN  639053
CAS DataBase Reference 5351-17-7(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 4-amino-, hydrazide(5351-17-7)

Safety information for 4-Aminobenzohydrazide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 4-Aminobenzohydrazide

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