4-AMino-5-Methylpyridin-2-ol

CAS NO.：95306-64-2
Empirical Formula: C6H8N2O
Molecular Weight: 124.14
MDL number: MFCD12546373
EINECS: 682-818-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-19 18:11:11

What is 4-AMino-5-Methylpyridin-2-ol?

Description

4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.

The Uses of 4-AMino-5-Methylpyridin-2-ol

4-Amino-5-methylpyridin-2(1H)-one has been used as a reactant for the synthesis of BAY 94-8862, a nonsteroidal antagonist of the mineralocorticoid receptor to be used for the treatment of cardiorenal diseases.

Synthesis

2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.

Properties of 4-AMino-5-Methylpyridin-2-ol

Boiling point:	291.0±33.0℃ (760 Torr)
Density	1.137±0.06 g/cm3 (20 ºC 760 Torr)
vapor pressure	0-0Pa at 20-50℃
Flash point:	129.8±25.4℃
storage temp.	2-8°C(protect from light)
pka	11.90±0.10(Predicted)
CAS DataBase Reference	95306-64-2

Safety information for 4-AMino-5-Methylpyridin-2-ol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.