4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

CAS NO.：182808-04-4
Empirical Formula: C10H10ClNO3
Molecular Weight: 227.64
Update Date: 2022-08-26 12:10:02

What is 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid?

The Uses of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

Methyl 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is an impurity of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. In addition, it is an intermediate in the preparation of enterokinetic agent R108512.

Properties of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

Boiling point:	425.1±45.0 °C(Predicted)
Density	1.407±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	-0.13±0.20(Predicted)

Safety information for 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

Abamectin manufacturer

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product: 182808-04-4 Prucalopride impurity D Methyl 4-amino-5chloro-2,3dihydrobenzofuran7-carboxylate 96%

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