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HomeProduct name list4-amino-2-fluoro-N-methylbenzamide

4-amino-2-fluoro-N-methylbenzamide

4-amino-2-fluoro-N-methylbenzamide Structural

What is 4-amino-2-fluoro-N-methylbenzamide?

The Uses of 4-amino-2-fluoro-N-methylbenzamide

4-?Amino-?2-?fluoro-?N-?methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors

Description

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

Preparation

2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.
4-amino-2-fluoro-N-methylbenzamide

Properties of 4-amino-2-fluoro-N-methylbenzamide

Melting point: 160 - 163°C
Boiling point: 320℃
Density  1.234
Flash point: 147℃
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 14.12±0.46(Predicted)
color  White to Off-White
Stability: Moisture Sensitive
InChI InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)

Safety information for 4-amino-2-fluoro-N-methylbenzamide

Computed Descriptors for 4-amino-2-fluoro-N-methylbenzamide

InChIKey XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES C(NC)(=O)C1=CC=C(N)C=C1F

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