AT-56

The Uses of AT-56

AT-56 is an orally active inhibitor of Lipocalin-type prostaglandin D synthase.

What are the applications of Application

AT-56 is AT-56 is a prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2.

in vitro

AT-56 (1-30 μM; 10 minutes) dose-dependently inhibits the production of PGD2 in L-PGDS-expressing human medulloblastoma TE-671 cells with an IC50 of about 3 μM.

in vivo

AT-56 (1-30 mg/kg; p.o.) suppresses the PGD2 production in the stab-wounded brain.
AT-56 (1-10 mg/kg; p.o.) suppresses the L-PGDS-mediated allergic airway inflammation in mice.
AT-56 (10 mg/kg; p.o.) exhibits Cmax (2.15 μg/ml), half-life (1.71 h) and high oral bioavailability (82%).

storage

Store at -20°C