4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER

Synonym(s):4-(Dimethylamino)azobenzene-4′-carboxylic acid N-succinimidyl ester;DABCYL-N-succinimidyl ester;Dabcyl-OSu;N-(4-[4Æ-(Dimethylamino)phenylazo]benzoyloxy)succinimide

CAS NO.：146998-31-4
Empirical Formula: C19H18N4O4
Molecular Weight: 366.37
MDL number: MFCD00467415
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 20:01:59

4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER Structural

What is 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER?

The Uses of 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER

Non-Fluorescent probe for labeling proteins or peptides

The Uses of 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER

4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups by forming stable peptide bonds. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for fluorescent studies of proteins. Its fluorescent properties (has a characteristic broad and intense visible absorption but has no fluorescence) make it an ideal long wavelength quencher and it has been utilized as an acceptor chromophore in FRET studies. It is also used for N-terminal modification of peptides in automated synthesis.

What are the applications of Application

4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester is a useful reagent for labeling proteins

Definition

ChEBI: Dabcyl SE dye is a pyrrolidinone and a monoazo compound. It has a role as a fluorochrome.

Properties of 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER

Melting point:	242 °C(dec.)
Boiling point:	550.7±60.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	Soluble in DMSO.
form	powder to crystal
pka	3.28±0.10(Predicted)
color	Light yellow to Amber to Dark green
Sensitive	Moisture Sensitive
CAS DataBase Reference	146998-31-4

Safety information for 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed.