4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER
Synonym(s):4-(Dimethylamino)azobenzene-4′-carboxylic acid N-succinimidyl ester;DABCYL-N-succinimidyl ester;Dabcyl-OSu;N-(4-[4Æ-(Dimethylamino)phenylazo]benzoyloxy)succinimide
- CAS NO.：146998-31-4
- Empirical Formula: C19H18N4O4
- Molecular Weight: 366.37
- MDL number: MFCD00467415
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER?
The Uses of 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER
Non-Fluorescent probe for labeling proteins or peptides
The Uses of 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER
4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups by forming stable peptide bonds. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for fluorescent studies of proteins. Its fluorescent properties (has a characteristic broad and intense visible absorption but has no fluorescence) make it an ideal long wavelength quencher and it has been utilized as an acceptor chromophore in FRET studies. It is also used for N-terminal modification of peptides in automated synthesis.
What are the applications of Application
4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester is a useful reagent for labeling proteins
Definition
ChEBI: Dabcyl SE dye is a pyrrolidinone and a monoazo compound. It has a role as a fluorochrome.
Properties of 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER
| Melting point: | 242 °C(dec.) |
| Boiling point: | 550.7±60.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO. |
| form | powder to crystal |
| pka | 3.28±0.10(Predicted) |
| color | Light yellow to Amber to Dark green |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 146998-31-4 |
Safety information for 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for 4-((4-(DIMETHYLAMINO)PHENYL)AZO)BENZOIC ACID, SUCCINIMIDYL ESTER
| InChIKey | IBOVDNBDQHYNJI-QZQOTICOSA-N |
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