4-(3-fluoro-benzyloxy)-benzaldehyde

CAS NO.：66742-57-2
Empirical Formula: C14H11FO2
Molecular Weight: 230.23
MDL number: MFCD02605317
EINECS: 613-982-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-11-13 13:40:13

What is 4-(3-fluoro-benzyloxy)-benzaldehyde?

The Uses of 4-(3-fluoro-benzyloxy)-benzaldehyde

4-(3-Fluorobenzyloxy)benzaldehyde is useful for organic reactions and synthesis.

Synthesis

4-(3-fluoro-benzyloxy)-benzaldehyde is synthesized by the reaction of 4-Hydroxybenzaldehyde with 3-fluorobenzyl bromide. 4-Hydroxybenzaldehyde, 3-fluorobenzyl bromide, potassium carbonate, and acetone were sequentially added to a single-neck round bottom flask. Reaction at 60 ° C for 5 h. Cool to room temperature, filter, and collect the filtrate.Purification by direct column chromatography. 4-(3-fluoro-benzyloxy)-benzaldehyde was obtained as a white solid (1.78 g, 94.4%).

Properties of 4-(3-fluoro-benzyloxy)-benzaldehyde

Melting point:	46.0 to 50.0 °C
Boiling point:	265°C/3mmHg(lit.)
Density	1.211±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
form	Solid:crystalline
color	White to Almost white
CAS DataBase Reference	66742-57-2

Safety information for 4-(3-fluoro-benzyloxy)-benzaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.