4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- CAS NO.:1818885-63-0
- Empirical Formula: C27H32N4O8
- Molecular Weight: 540.57
- Update Date: 2024-07-02 08:54:57
What is 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione?
Description
Pomalidomide-PEG4-Ph-NH2 is comprised of the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Pomalidomide-PEG4-Ph-NH2 is used in PROTAC technology as a E3 ligase ligand-linker conjugate that incorporates PEG technology that can be linked to a wide range of "warheads" that bind to proteins of interest.
Properties of 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Boiling point: | 792.0±60.0 °C(Predicted) |
Density | 1.363±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
pka | 10.74±0.40(Predicted) |
form | Solid |
color | Light yellow to yellow |
Safety information for 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
New Products
Tubulysin H Tubulysin C Tubulysin I (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Potassium HMDS (1.0 M in THF) 2H-Pyran, 4-ethynyltetrahydro- 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropanol 4,4-DIFLUOROCYCLOHEXANAMINE CYCLOBUTYLAMINE HYDROCHLORIDE Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
E3 ligase Ligand-Linker Conjugates 14
E3 ligase Ligand-Linker Conjugates 17
N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
Thalidomide-O-amido-C3-NH2 (TFA)
E3 ligase Ligand-Linker Conjugates 5 Free Base
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
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