4-(1-Acetylpiperazin-4-yl)phenol
- CAS NO.：67914-60-7
- Empirical Formula: C12H16N2O2
- Molecular Weight: 220.27
- MDL number: MFCD00044905
- EINECS: 267-744-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-28 16:00:23
What is 4-(1-Acetylpiperazin-4-yl)phenol?
Chemical properties
Off-White Solid
The Uses of 4-(1-Acetylpiperazin-4-yl)phenol
1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs.
General Description
1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP), a piperazine derivative, is a structural analog of acetaminophen. Its multi-step preparation using bis-(2-chloroethyl)amine hydrochloride and p-aminophenol as starting materials has been reported.2
Flammability and Explosibility
Not classified
Properties of 4-(1-Acetylpiperazin-4-yl)phenol
| Melting point: | 180-185 °C (lit.) |
| Boiling point: | 361.21°C (rough estimate) |
| Density | 1.1115 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 12.18±0.30(Predicted) |
| color | White to slightly pink or beige |
| Water Solubility | 4.3 g/L (20 ºC) |
| BRN | 795777 |
| CAS DataBase Reference | 67914-60-7(CAS DataBase Reference) |
Safety information for 4-(1-Acetylpiperazin-4-yl)phenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(1-Acetylpiperazin-4-yl)phenol
| InChIKey | AGVNLFCRZULMKK-UHFFFAOYSA-N |
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