4-(1-Acetylpiperazin-4-yl)phenol
- CAS NO.:67914-60-7
- Empirical Formula: C12H16N2O2
- Molecular Weight: 220.27
- MDL number: MFCD00044905
- EINECS: 267-744-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-(1-Acetylpiperazin-4-yl)phenol?
Chemical properties
Off-White Solid
The Uses of 4-(1-Acetylpiperazin-4-yl)phenol
1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs.
General Description
1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP), a piperazine derivative, is a structural analog of acetaminophen. Its multi-step preparation using bis-(2-chloroethyl)amine hydrochloride and p-aminophenol as starting materials has been reported.2
Flammability and Explosibility
Not classified
Properties of 4-(1-Acetylpiperazin-4-yl)phenol
Melting point: | 180-185 °C (lit.) |
Boiling point: | 361.21°C (rough estimate) |
Density | 1.1115 (rough estimate) |
vapor pressure | 0Pa at 20℃ |
refractive index | 1.6000 (estimate) |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Powder |
pka | 12.18±0.30(Predicted) |
color | White to slightly pink or beige |
Water Solubility | 4.3 g/L (20 ºC) |
BRN | 795777 |
CAS DataBase Reference | 67914-60-7(CAS DataBase Reference) |
Safety information for 4-(1-Acetylpiperazin-4-yl)phenol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(1-Acetylpiperazin-4-yl)phenol
InChIKey | AGVNLFCRZULMKK-UHFFFAOYSA-N |
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New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
Ketoconazole Impurity 2
KetoconazoleN-Oxide
2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL METHYL)-1,3-DIOXOLANE-4-METHANOL
Ketoconazole Impurity 4
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
rac-trans-Ketoconazole
2,3-Dehydro Ketoconazole
Ketoconazole Impurity 11
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