(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
- CAS NO.:915095-94-2
- Empirical Formula: C17H16ClIO2
- Molecular Weight: 414.67
- MDL number: MFCD28098707
- EINECS: 619-599-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-12 21:58:09
What is (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran?
Description
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.
Preparation
0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.
Properties of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Boiling point: | 476.0±45.0 °C(Predicted) |
Density | 1.578±0.06 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C(protect from light) |
solubility | DMSO, Methanol (Slightly, Sonicated) |
form | Solid |
color | White to Off-White |
InChI | InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1 |
CAS DataBase Reference | 915095-94-2 |
Safety information for (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
InChIKey | YLUHNGIWRCCQMQ-INIZCTEOSA-N |
SMILES | O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1 |
Abamectin manufacturer
PALEM ORGANICS PVT LTD
Aarti Industries Limited (AIL)
Lakshmi Farmachem
Stereokem Pvt Ltd
Rivashaa Agrotech Biopharma Pvt. Ltd.
Bakul Pharma Private Limited
Related products of tetrahydrofuran
You may like
-
915095-94-2 (3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc 98%View Details
915095-94-2 -
915095-94-2 98%View Details
915095-94-2 -
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 98%View Details
915095-94-2 -
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 98%View Details
-
915095-94-2 (S)-3-(4-(2-chloro-5- iodobenzyl) phenoxy) tetrahydrofuran 99%View Details
915095-94-2 -
(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene 915095-94-2 99%View Details
915095-94-2 -
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2 99%View Details
915095-94-2 -
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 98%View Details