3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

CAS NO.：396731-40-1
Empirical Formula: C10H15NO4
Molecular Weight: 213.23
MDL number: MFCD14706038
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 15:13:27

What is 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester?

The Uses of 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis_396731-40-1
To a cooled (5 ??C) and stirred mixture of potassium 2-methyl-2-propoxide (29.7 g,0.27 mol) was added a solution of ethyl [A/-((1,1-dimethylethoxy)carbonyl),A/-(2-oxopropyl)]glycinate (65 g, 0.25 mol) in ethyl ether (200 ml) over a period of 1.5 h. The re- sulting mixture was stirred for an additional 3 h, and the formed precipitate was filtered offand washed with ethyl ether (2 x 100 ml). The solid was dissolved in water (150 ml), andacetic acid was added to adjust the pH to 4. The product was filtered, washed with water (2x 50 ml) and air dried to furnish 1 -[(1,1 -dimethylethoxy)carbonyl]-3,5-dioxopiperidine (28 g,52 %).>xxN'TOHPLC-MS: m/z: 158 (M+H-56).1H-NMR (DMSO-d6): 81.48 (9H, s), 4.03 (4H, s), 5.38 (1 H, s).

Properties of 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

Boiling point:	346.2±32.0 °C(Predicted)
Density	1.199±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	9.72±0.20(Predicted)
color	Light yellow to yellow
CAS DataBase Reference	396731-40-1

Safety information for 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

Computed Descriptors for 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

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