3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID

CAS NO.：101-29-1
Empirical Formula: C7H5I2NO3
Molecular Weight: 404.93
MDL number: MFCD00006185
EINECS: 202-932-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:30

What is 3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID?

Originator

Iodopyracet,Winthrop

The Uses of 3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID

3,5-Diiodo-4-pyridone-1-acetic Acid is used in contrast media.

Definition

ChEBI: Diodone is a 4-pyridone in which the pyridone is iodo-substituted at C-3 and -5 and has a carboxymethyl substituent on nitrogen; used as a radiocontrast agent urography. It has a role as a radioopaque medium. It is a member of 4-pyridones, a monocarboxylic acid and an organoiodine compound.

Manufacturing Process

2 mol of pyridine are reacted with thionyl chloride to give 4-pyridyl-pyridinium chloride. The last one is transformed into 4-1H-pyridone by adding of water at 150°C. Then it is added to 1 mol of iodomonochloride (ICl) to give 3,5- diidopyridone. It is converted in 3.5-diiodo-4-pyridone-N-acetic acid by addition of chloroacetic acid and sodium hydrate. 1 mol of 3.5-diiodo-4- pyridone-N-acetic acid is dissolved in a solution of 1 mol of diethanolamine in 60 ml of water while heating. The solution is made up to 100 ml with water. After evaporating the solution and recrystallizing, the salt is obtained in the form of white crystals. MP: 153°C.

Therapeutic Function

Diagnostic aid

Properties of 3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID

Melting point:	244°C (dec.)
Boiling point:	422.8±45.0 °C(Predicted)
Density	2.2000 (rough estimate)
refractive index	1.7400 (estimate)
pka	3.60±0.10(Predicted)
Water Solubility	2.787g/L(temperature not stated)
Sensitive	Light Sensitive
CAS DataBase Reference	101-29-1(CAS DataBase Reference)

Safety information for 3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.