3,5-Di-tert-butylsalicylaldehyde
Synonym(s):3,5-Di-tert-butylsalicylaldehyde
- CAS NO.:37942-07-7
- Empirical Formula: C15H22O2
- Molecular Weight: 234.33
- MDL number: MFCD00191998
- EINECS: 629-676-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-02 14:14:00
What is 3,5-Di-tert-butylsalicylaldehyde?
Chemical properties
3,5-Di-tert-butylsalicylaldehyde is white to yellow powder or chunks or crystal or crystalline powder
The Uses of 3,5-Di-tert-butylsalicylaldehyde
3,5-Di-tert-butylsalicylaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-tert-butylsalicylaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).
The Uses of 3,5-Di-tert-butylsalicylaldehyde
3,5-Di-tert-butyl-2-hydroxybenzaldehyde is used in the synthesis of Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose, chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenyl acetylene to imines, chiral oxazolidine ligand for the enantioselective addition of diethyl zinc to aldehydes and tin Schiff base complexes with histidine analogues. It has antibacterial activity and is used in the preparation nickel complexes. It is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).
The Uses of 3,5-Di-tert-butylsalicylaldehyde
3,5-Di-tert-butyl-2-hydroxybenzaldehyde was used in the synthesis of
- Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose
- chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenylacetylene to imines
- chiral oxazolidine ligand for the enantioselective addition of diethylzinc to aldehydes
- tin Schiff base complexes with histidine analogues
Definition
ChEBI: 3,5-di-tert-butyl-2-hydroxybenzaldehyde is a hydroxybenzaldehyde.
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 1939, 1994 DOI: 10.1021/jo00086a062
Tetrahedron, 46, p. 793, 1990 DOI: 10.1016/S0040-4020(01)81362-4
Tetrahedron Letters, 13, p. 4205, 1972 DOI: 10.1016/S0040-4039(01)94276-5
General Description
3,5-Di-tert-butyl-2-hydroxybenzaldehyde undergoes condensation reaction with
- methyl-2-{N-(2′-aminoethane)}-amino-1-cyclopentenedithiocarboxylate to yield Schiff base ligand
- N,N-diethyl-2-methyl-1,4-phenylenediamine during the synthesis of copper(II) and cobalt(II) complexes of salicylaldimine
Properties of 3,5-Di-tert-butylsalicylaldehyde
Melting point: | 59-61 °C(lit.) |
Boiling point: | 277.6±35.0 °C(Predicted) |
Density | 1.006±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in DMSO and methanol. |
pka | 9.78±0.23(Predicted) |
form | Solid |
color | Off-White to Light Yellow |
Sensitive | Air Sensitive |
BRN | 1877810 |
CAS DataBase Reference | 37942-07-7(CAS DataBase Reference) |
Safety information for 3,5-Di-tert-butylsalicylaldehyde
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,5-Di-tert-butylsalicylaldehyde
InChIKey | RRIQVLZDOZPJTH-UHFFFAOYSA-N |
3,5-Di-tert-butylsalicylaldehyde manufacturer
Dr. Silviu Pharmachem Pvt., Ltd.
BASR Fine Chemicals Pvt. Ltd.
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