Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list3,5-Bis(trifluoromethyl)benzyl bromide

3,5-Bis(trifluoromethyl)benzyl bromide

Synonym(s):1-(Bromomethyl)-3,5-bis(trifluoromethyl)benzene

  • CAS NO.:32247-96-4
  • Empirical Formula: C9H5BrF6
  • Molecular Weight: 307.03
  • MDL number: MFCD00009905
  • EINECS: 250-971-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-25 17:47:29
3,5-Bis(trifluoromethyl)benzyl bromide Structural

What is 3,5-Bis(trifluoromethyl)benzyl bromide?

Chemical properties

White or Colorles to Yellow to Orange powder to lump to clear liquid

The Uses of 3,5-Bis(trifluoromethyl)benzyl bromide

3,5-Bis(trifluoromethyl)benzyl bromide is used as derivatization reagent in detection of uracil in DNA by GC and negative chemical ionization mass spectrometry in enantioselective synthesis of non-peptidic neurokinin NK1 receptor antagonist.

Synthesis

Synthesis of 3, 5-bis (trifluoromethyl)-benzyl bromide:
In a 4-neck flask with capacity 1000 ml equipped with mechanical agitator, thermometer, bubble condenser and 100 ml loading funnel, 262.2 g of the product of Example 1 (ii) at 92. 8% (0. 988 moles), 550,2 g HBr 48% (3.2645 moles) are loaded; this is heated at 50°C so as to melt the alcohol, then one starts to dose 113 g of concentrated His04 (1.153 moles). Pouring is accomplished in 30 minutes, noting an increase of the internal temperature. This is heated to 100-105°C and left to react for 8 hours. The reaction is completed by reflux heating for per 1.5 hours. the mixture is left to settle and the phases are separated; the solvents are removed from the organic phase and the product in the title is obtained with a yield of 99.1 %.
Synthesis of 3, 5-bis (trifluoromethyl)-benzyl bromide.png

Properties of 3,5-Bis(trifluoromethyl)benzyl bromide

Melting point: 18°C
Boiling point: 136-140°C 14mm
Density  1.675 g/mL at 25 °C(lit.)
refractive index  n20/D 1.445(lit.)
Flash point: 79 °F
storage temp.  Inert atmosphere,2-8°C
solubility  Difficult to mix.
form  Liquid
Specific Gravity 1.675
color  Clear colorless to yellow-brown
Sensitive  Lachrymatory
BRN  656506
CAS DataBase Reference 32247-96-4(CAS DataBase Reference)
NIST Chemistry Reference 3,5-Bis(trifluoromethyl)benzyl bromide(32247-96-4)

Safety information for 3,5-Bis(trifluoromethyl)benzyl bromide

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H226:Flammable liquids
H314:Skin corrosion/irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3,5-Bis(trifluoromethyl)benzyl bromide

Related products of tetrahydrofuran

You may like

  • 3,5-Bis(trifluoromethyl)benzyl Bromide CAS 32247-96-4
    3,5-Bis(trifluoromethyl)benzyl Bromide CAS 32247-96-4
    32247-96-4
    View Details
  • 3,5-Bis(trifluoromethyl)benzyl bromide CAS 32247-96-4
    3,5-Bis(trifluoromethyl)benzyl bromide CAS 32247-96-4
    32247-96-4
    View Details
  • Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate 99%
    Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate 99%
    54094-19-8
    View Details
  • 85-81-4 99%
    85-81-4 99%
    85-81-4
    View Details
  • 208111-98-2 (3aR,4R,5R,6aS)-5-(Benzoyloxy)hexahydro-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten- 1-yl]-2H-cyclopenta[b]furan-2-one 99%
    208111-98-2 (3aR,4R,5R,6aS)-5-(Benzoyloxy)hexahydro-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten- 1-yl]-2H-cyclopenta[b]furan-2-one 99%
    208111-98-2
    View Details
  • 2033-24-1 99%
    2033-24-1 99%
    2033-24-1
    View Details
  • Meldrums acid 2033-24-1 99%
    Meldrums acid 2033-24-1 99%
    2033-24-1
    View Details
  • 2-Aminopyridine 504-29-0 99%
    2-Aminopyridine 504-29-0 99%
    504-29-0
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.