3,4-Dimethoxyphenylacetone

CAS NO.：776-99-8
Empirical Formula: C11H14O3
Molecular Weight: 194.23
MDL number: MFCD00008772
EINECS: 212-285-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-23 18:28:04

What is 3,4-Dimethoxyphenylacetone?

Chemical properties

CLEAR YELLOW TO BROWN LIQUID

The Uses of 3,4-Dimethoxyphenylacetone

3,4-Dimethoxyphenylacetone was used as starting material in the synthesis of α-methyl-dopa, an important nonproteogenic α-amino acid for pharmaceutical applications. 3,4-Dimethoxyphenylacetone undergoes asymmetric amination catalyzed by Brevibacterium linens IFO 12141 strain to yield corresponding optically active amine

Synthesis Reference(s)

Chemistry Letters, 5, p. 1239, 1976
The Journal of Organic Chemistry, 29, p. 1424, 1964 DOI: 10.1021/jo01029a039

Properties of 3,4-Dimethoxyphenylacetone

Melting point:	136-139 °C
Boiling point:	154-158 °C (12 mmHg)
Density	1.115 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5358(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	clear liquid
color	Light yellow to Yellow to Orange
Water Solubility	Insoluble in water.
BRN	1107410
CAS DataBase Reference	776-99-8(CAS DataBase Reference)
NIST Chemistry Reference	3,4-Dimethoxyphenylacetone(776-99-8)

Safety information for 3,4-Dimethoxyphenylacetone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.