3-Quinuclidinol
Synonym(s):1-Azabicyclo[2.2.2]octan-3-ol;3-Hydroxyquinuclidine
- CAS NO.：1619-34-7
- Empirical Formula: C7H13NO
- Molecular Weight: 127.18
- MDL number: MFCD00151326
- EINECS: 216-578-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:42:50
What is 3-Quinuclidinol?
Chemical properties
Crystalline Solid
The Uses of 3-Quinuclidinol
3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.
The Uses of 3-Quinuclidinol
Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics
Definition
ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.
Hazard
Mutation.
Properties of 3-Quinuclidinol
| Melting point: | 220-223 °C(lit.) |
| Boiling point: | 235.98°C (rough estimate) |
| Density | 1.0083 (rough estimate) |
| refractive index | 1.4790 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly) |
| pka | 14.75±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| Merck | 14,8082 |
| BRN | 104327 |
| CAS DataBase Reference | 1619-34-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Quinuclidinol(1619-34-7) |
| EPA Substance Registry System | 1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7) |
Safety information for 3-Quinuclidinol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Quinuclidinol
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