3-Methoxysalicylaldehyde

Synonym(s):2-Hydroxy-m-anisaldehyde;2-Hydroxy-3-methoxybenzaldehyde;3-Methoxysalicylaldehyde

CAS NO.：148-53-8
Empirical Formula: C8H8O3
Molecular Weight: 152.15
MDL number: MFCD00003322
EINECS: 205-715-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 3-Methoxysalicylaldehyde?

Chemical properties

Pale yellow to brown low melting solid

The Uses of 3-Methoxysalicylaldehyde

A positional isomer of Vanillin. o-Vanillin is a more potent antioxidant than Vanillin.

The Uses of 3-Methoxysalicylaldehyde

o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII). It is also used in the study of mutagenesis and as a synthetic precursor for pharmaceuticals.

The Uses of 3-Methoxysalicylaldehyde

o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII).

Definition

ChEBI: A member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3.

Hazard

ortho-Vanillin is harmful if ingested, irritating to eyes, skin and respiratory system, but has an unmistakable high LD50 of 1330 mg/kg in mice.

Biochem/physiol Actions

o-Vanillin induces DNA damage as detected by comet assay.

Properties of 3-Methoxysalicylaldehyde

Melting point:	40-42 °C (lit.)
Boiling point:	265-266 °C (lit.)
Density	1.2143 (rough estimate)
refractive index	1.4945 (estimate)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	pK1:7.912 (25°C)
form	Low Melting Solid
color	Pale yellow to brown
Water Solubility	slightly soluble
Sensitive	Air Sensitive
BRN	471913
Stability:	Hygroscopic
CAS DataBase Reference	148-53-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzaldehyde, 2-hydroxy-3-methoxy-(148-53-8)
EPA Substance Registry System	Benzaldehyde, 2-hydroxy-3-methoxy- (148-53-8)

Safety information for 3-Methoxysalicylaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.