3-HYDROXY-2-NAPHTHOIC ACID HYDRAZIDE

Synonym(s):3-Hydroxy-2-naphthydrazide

beige powder

3-Hydroxy-2-naphthoic hydrazide may be used to synthesize the following 2-(alkyl/arylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazoles:

2-ethylamino-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-phenethylamino-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-phenylamino-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(p-bromophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(p-chlorophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(p-fluorophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(m-fluorophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(p-methoxyphenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(p-methylphenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
2-(m-trifluoromethylphenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole

It may also be employed for the synthesis of 3-hydroxy-2-naphthaldehyde.

Melting point:	205-208 °C (lit.) 205-208 °C
Boiling point:	340.32°C (rough estimate)
Density	1.352
refractive index	1.5300 (estimate)
pka	8.86±0.40(Predicted)
form	Powder
color	Beige
BRN	395153
CAS DataBase Reference	5341-58-2(CAS DataBase Reference)
EPA Substance Registry System	2-Naphthalenecarboxylic acid, 3-hydroxy-, hydrazide (5341-58-2)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.