3-BROMO-4-CHLOROANILINE
- CAS NO.：823-54-1
- Empirical Formula: C6H5BrClN
- Molecular Weight: 206.47
- MDL number: MFCD00173905
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-25 13:42:50
What is 3-BROMO-4-CHLOROANILINE?
Description
3-Bromo-4-chloroaniline can be used as an intermediate in pharmaceutical synthesis, such as the preparation of Vismodegib, the trade name is Erivedge, the chemical name is 2-chloro-N-(4-chloro-3 -(Pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, developed by Curis, Genentech and Evotec in cooperation, was approved by the U.S. Food and Drug Administration (FDA) on January 30, 2012 ) marketing approval as a small molecule targeted inhibitor of the Hedgehog pathway for the treatment of basal cell carcinoma.
The Uses of 3-BROMO-4-CHLOROANILINE
3-Bromo-4-chloroaniline is an amine derivative and can be used as an organic reagent.
Synthesis
Dissolve p-chloronitrobenzene in sulfuric acid aqueous solution, slowly add bromine reagent (bromine or potassium bromate), and react to obtain 3-bromo-4-chloroaniline.
Properties of 3-BROMO-4-CHLOROANILINE
| Melting point: | 82°C |
| Boiling point: | 290.6±20.0℃ (760 Torr) |
| Density | 1.722±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point: | 129.5±21.8℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 2.89±0.10(Predicted) |
| color | White to Brown |
Safety information for 3-BROMO-4-CHLOROANILINE
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 3-BROMO-4-CHLOROANILINE
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product: 823-54-1 98%
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