Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list3-Aminobenzeneboronic acid hemisulfate salt

3-Aminobenzeneboronic acid hemisulfate salt

Synonym(s):(m-Aminophenyl)boronic acid hemisulfate;(3-Aminophenyl)boric acid hemisulfate;(3-aminophenyl)-boronic acid sulfate (2:1);3-Aminobenzeneboronic acid hemisulfate salt;Bis[3-dihydroxyboranyl)benzenaminium] sulfate

  • CAS NO.:66472-86-4
  • Empirical Formula: C12H18B2N2O8S
  • Molecular Weight: 371.96692
  • MDL number: MFCD00013111
  • EINECS: 266-376-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
3-Aminobenzeneboronic acid hemisulfate salt Structural

What is 3-Aminobenzeneboronic acid hemisulfate salt?

Chemical properties

White to slightly beige crystalline powder

The Uses of 3-Aminobenzeneboronic acid hemisulfate salt

3-Aminobenzeneboronic acid hemisulfate salt is a boronic acid derivative, which can be used as an intermediate in pharmaceutical synthesis. Adsorbent additive for the chromatographic separation of 3'-terminal polynucleotides from RNA.

What are the applications of Application

3-Aminophenylboronic acid hemisulfate salt is used in the synthesis of:
Phenylboronic acid-functionalized inverse opal hydrogels within microfluidic flow cells for glucose sensing.
Phenylboronic acid-salicylhydroxamic acid-derived complexing reagent for protein immobilization on chromatographic support.
It can also be used in the preparation of phenylboronic acid (PBA) monolayer-modified Au electrode for the voltammetric sensing of uridine and cytidine.

Preparation

3-Aminobenzeneboronic acid hemisulfate salt synthesis: Benzenamine, 3-bromo-N-(diphenylmethylene)- (80,0 g; 0.24 moles) was added to the cryogenic reactor along with 1.4 equivalents of triisopropyl borate and dissolved in tetrahydrofuran. The resulting solution was cooled to -80°C under an inert atmosphere and 1.35 equivalents of n-butyllithium (as a solution in n-hexane) was added maintaining the internal temperature. When complete conversion was achieved, the reaction mixture was added to a dilute mixture of sulfuric acid (1 M) and toluene. The layers were separated to obtain an aqueous solution of 3-aminophenylboronic acid hydrogen sulfate (assay yield: 85%). 3-Aminobenzeneboronic acid hemisulfate salt can be obtained by precipitating a 0.5 M aqueous solution at pH 7.2 (pH corrected with 33% aqueous NaOH) at a temperature of 0-5°C. Filtration and drying under vacuum at 40°C for 8 hours yielded 21.7 g of 3-Aminobenzeneboronic acid hemisulfate salt (0.16 moles; 66% molar yield).

Properties of 3-Aminobenzeneboronic acid hemisulfate salt

Melting point: ≥300 °C
storage temp.  Inert atmosphere,2-8°C
Water Solubility  Soluble in water
form  Crystalline Powder
color  White to slightly beige
Sensitive  Hygroscopic
BRN  8094151
CAS DataBase Reference 66472-86-4

Safety information for 3-Aminobenzeneboronic acid hemisulfate salt

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 3-Aminobenzeneboronic acid hemisulfate salt

InChIKey XMVGYYBQCXVVHU-UHFFFAOYSA-N

Related products of tetrahydrofuran

You may like

  • 66472-86-4 3-Aminophenylboronic acid hemisulfate 99%
    66472-86-4 3-Aminophenylboronic acid hemisulfate 99%
    66472-86-4
    View Details
  • 66472-86-4 99%
    66472-86-4 99%
    66472-86-4
    View Details
  • 3-Aminophenylboronic acid hemisulfate CAS 66472-86-4
    3-Aminophenylboronic acid hemisulfate CAS 66472-86-4
    66472-86-4
    View Details
  • 3-Aminophenylboronic acid hemisulphate, 95% CAS 66472-86-4
    3-Aminophenylboronic acid hemisulphate, 95% CAS 66472-86-4
    66472-86-4
    View Details
  • 3-Aminophenylboronic Acid Hemisulfate CAS 66472-86-4
    3-Aminophenylboronic Acid Hemisulfate CAS 66472-86-4
    66472-86-4
    View Details
  • 3-Aminophenylboronic acid hemisulfate salt CAS 66472-86-4
    3-Aminophenylboronic acid hemisulfate salt CAS 66472-86-4
    66472-86-4
    View Details
  • Edoxaban Impurity 57
    Edoxaban Impurity 57
    2089454-69-1
    View Details
  • Empagliflozin Bromo Impurity
    Empagliflozin Bromo Impurity
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.