3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

Synonym(s):3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide

CAS NO.：409351-28-6
Empirical Formula: C18H19N3O2S
Molecular Weight: 341.43
MDL number: MFCD02742972
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Structural

What is 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide?

The Uses of 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

VU 152100 is a positive allosteric modulator of muscarinic choline receptor M4.

What are the applications of Application

VU 152100 is a positive allosteric modulator of muscarinic choline receptor M4

Biological Activity

vu0152100 is a selective and positive allosteric modulators of m4 receptor with the ec50 value of 380±93nm[1].vu0152100 has shown a potent positive allosteric modulators that increase the response of the m4 receptor to the endogenous agonist ach in in vitro study. in addition, vu0152100 has been reported to dese-dependently potentiate the response to the agonist (ach) with the ec50 value of 1.9±0.2μm, and increase the maximal response to ach to approximately 130%. furthermore, vu0152100 has been revealed to enhance receptor activation by increasing the affinity of m4 for acetylcholine. apart from these, vu0152100 has been found to induce a 20 to 25-fold leftward shift in the potency of ach to displace [3h]nms binding to m4 receptor with the ki value from 252±19.7nm to 12.2±0.49nm [1].

storage

Store at RT

References

[1] brady ae1, jones ck, bridges tm, kennedy jp, thompson ad, heiman ju, breininger ml, gentry pr, yin h, jadhav sb, shirey jk, conn pj, lindsley cw. centrally active allosteric potentiators of the m4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. j pharmacol exp ther. 2008 dec;327(3):941-53.

Properties of 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

Density	1.282
storage temp.	Store at RT
solubility	DMSO: >50mg/mL
form	powder
color	Light yellow to khaki

Safety information for 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

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