3-Amino-5-fluoropyridine
Synonym(s):(5-Fluoropyridin-3-yl)amine;3-Amino-5-fluoropyridine;5-Fluoropyridin-3-amine
- CAS NO.:210169-05-4
- Empirical Formula: C5H5FN2
- Molecular Weight: 112.11
- MDL number: MFCD00234073
- EINECS: 664-255-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-01 19:39:48
What is 3-Amino-5-fluoropyridine?
Chemical properties
Light yellow Crystal
The Uses of 3-Amino-5-fluoropyridine
3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults.
What are the applications of Application
Reactant for:
Preparation of nonpeptide inhibitors of measles virus entry.
Preparation
synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);
IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29.
Properties of 3-Amino-5-fluoropyridine
Melting point: | 86°C |
Boiling point: | 232.7±20.0 °C(Predicted) |
Density | 1.257±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
form | powder to crystal |
pka | 3.74±0.20(Predicted) |
color | Light orange to Yellow to Green |
CAS DataBase Reference | 210169-05-4(CAS DataBase Reference) |
Safety information for 3-Amino-5-fluoropyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Amino-5-fluoropyridine
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