(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
Synonym(s):(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime;(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one;6-Bromoindirubin acetoxime;6-Bromoindirubin-3′-acetoxime;BIA
- CAS NO.：667463-85-6
- Empirical Formula: C18H12BrN3O3
- Molecular Weight: 398.21
- MDL number: MFCD09037533
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME?
The Uses of (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Biological Activity
Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
storage
Store at +4°C
Properties of (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
| Density | 1.69±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | H2O: soluble2mg/mL (clear solution, warmed) |
| pka | 9.22±0.20(Predicted) |
| form | powder |
| color | dark red to purple |
Safety information for (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
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