(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

Synonym(s):(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime;(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one;6-Bromoindirubin acetoxime;6-Bromoindirubin-3′-acetoxime;BIA

CAS NO.：667463-85-6
Empirical Formula: C18H12BrN3O3
Molecular Weight: 398.21
MDL number: MFCD09037533
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Structural

What is (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME?

The Uses of (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Biological Activity

Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

storage

Store at +4°C

Properties of (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

Density	1.69±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	H2O: soluble2mg/mL (clear solution, warmed)
pka	9.22±0.20(Predicted)
form	powder
color	dark red to purple

Safety information for (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..…

Computed Descriptors for (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

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