2,6-Dichloro-3-nitropyridine
- CAS NO.:16013-85-7
- Empirical Formula: C5H2Cl2N2O2
- Molecular Weight: 192.99
- MDL number: MFCD00006234
- EINECS: 240-151-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-13 18:00:15
What is 2,6-Dichloro-3-nitropyridine?
Chemical properties
yellow crystalline powder or chunks
The Uses of 2,6-Dichloro-3-nitropyridine
2,6-Dichloro-3-nitropyridine was used:
- in the synthesis of pyridyldifluoroacetates
- as starting reagent in the preparation of bicyclooxacalixhetarene
Definition
Nitropyridine nucleus played a pivotal role in the development of different medicinal agents and in the field of agrochemicals. It is seen from the current literature that pyridine derivatives have been developed and used as insecticidal agents. Nitrated pyridines and their derivatives are important intermediates in synthesis of heterocyclic compounds in dyes and pharmaceutical products. Fused heterocycles containing nitropyridine systems have been associated with several biological and medicinal activities including antiolytic, antiviral and anti-inflammatory profiles.
General Description
2,6-Dichloro-3-nitropyridine undergoes macrocyclic condensation reaction with resorcinol derivatives to yield chiral tetraoxacalix[2]arene[2]pyridines.
Structure and conformation
The asymmetric unit of 2,6-Dichloro-3-nitropyridine consists of two crystallographically independent mol-ecules. The pyridine ring in each mol-ecule is essentially planar, with maximum deviations of 0.004 (4) and 0.007 (4)Å. Short Cl-O [3.09?(3) and 3.13 (4)Å] and Cl-Cl [3.38 (12)Å] contacts were observed. No significant inter-molecular inter-actions were observed in the crystal packing.
Properties of 2,6-Dichloro-3-nitropyridine
Melting point: | 55-60 °C(lit.) |
Boiling point: | 295.5±35.0 °C(Predicted) |
Density | 1.6791 (rough estimate) |
refractive index | 1.6100 (estimate) |
Flash point: | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
form | Liquid |
pka | -5.76±0.10(Predicted) |
color | Clear colorless to light yellow |
BRN | 1619741 |
InChI | InChI=1S/C5H2Cl2N2O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H |
CAS DataBase Reference | 16013-85-7(CAS DataBase Reference) |
Safety information for 2,6-Dichloro-3-nitropyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,6-Dichloro-3-nitropyridine
InChIKey | SHCWQWRTKPNTEM-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC(Cl)=CC=C1[N+]([O-])=O |
2,6-Dichloro-3-nitropyridine manufacturer
Gravitas Pharma Pvt Ltd
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
RPN ORGANICS PVT LTD
Sintilla Medcoms Pvt Ltd
Dr. Silviu Pharmachem Pvt., Ltd.
Dr R R Organics
Clarity Research Laboratory
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