25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
- CAS NO.:136632-32-1
- Empirical Formula: C19H35N3O4S1
- Molecular Weight: 401.56
- MDL number: MFCD00065506
- EINECS: 603-969-3
- Update Date: 2023-05-18 11:30:58
What is 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE?
Description
ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.
The Uses of 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
The Uses of 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.
What are the applications of Application
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins
Definition
ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide.
References
1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421
Properties of 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
storage temp. | −20°C |
solubility | Soluble in ethanol at 20mg/ml |
form | powder |
color | white |
BRN | 7693643 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Safety information for 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
Computed Descriptors for 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
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