2',5'-Dimethoxyacetophenone

CAS NO.：1201-38-3
Empirical Formula: C10H12O3
Molecular Weight: 180.2
MDL number: MFCD00008728
EINECS: 214-858-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-27 13:06:06

What is 2',5'-Dimethoxyacetophenone?

Chemical properties

clear yellow to green-yellow liquid

The Uses of 2',5'-Dimethoxyacetophenone

2'',5''-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents.

Preparation

Obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide.

Synthesis

2',5'-Dimethoxyacetophenone is prepared from Hydroquinone dimethylether and Acetic anhydride with Aluminum chloride catalyst.

Properties of 2',5'-Dimethoxyacetophenone

Melting point:	18-20 °C(lit.)
Boiling point:	155-158 °C11 mm Hg(lit.)
Density	1.139 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5441(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol (Slightly)
form	Liquid
color	Clear yellow to green-yellow
BRN	2047423
CAS DataBase Reference	1201-38-3(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(2,5-dimethoxyphenyl)-(1201-38-3)
EPA Substance Registry System	Ethanone, 1-(2,5-dimethoxyphenyl)- (1201-38-3)

Safety information for 2',5'-Dimethoxyacetophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.