2',5'-Dimethoxyacetophenone
- CAS NO.：1201-38-3
- Empirical Formula: C10H12O3
- Molecular Weight: 180.2
- MDL number: MFCD00008728
- EINECS: 214-858-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-12 14:24:31
What is 2',5'-Dimethoxyacetophenone?
Chemical properties
clear yellow to green-yellow liquid
The Uses of 2',5'-Dimethoxyacetophenone
2'',5''-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents.
Preparation
Obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide.
Synthesis
2',5'-Dimethoxyacetophenone is prepared from Hydroquinone dimethylether and Acetic anhydride with Aluminum chloride catalyst.
Properties of 2',5'-Dimethoxyacetophenone
| Melting point: | 18-20 °C(lit.) |
| Boiling point: | 155-158 °C11 mm Hg(lit.) |
| Density | 1.139 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol (Slightly) |
| form | Liquid |
| color | Clear yellow to green-yellow |
| BRN | 2047423 |
| CAS DataBase Reference | 1201-38-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(2,5-dimethoxyphenyl)-(1201-38-3) |
| EPA Substance Registry System | Ethanone, 1-(2,5-dimethoxyphenyl)- (1201-38-3) |
Safety information for 2',5'-Dimethoxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2',5'-Dimethoxyacetophenone
| InChIKey | FAXUIYJKGGUCBO-UHFFFAOYSA-N |
2',5'-Dimethoxyacetophenone manufacturer
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product: 1-(2,5-Dimethoxyphenyl)ethanone 98%
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