2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
- CAS NO.:6713-54-8
- Empirical Formula: C6H4N4O4
- Molecular Weight: 196.12
- MDL number: MFCD00129147
- EINECS: 229-766-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine?
The Uses of 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops.
Synthesis
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.
Properties of 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
Density | 1.89±0.1 g/cm3(Predicted) |
pka | 5.90±0.20(Predicted) |
Safety information for 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
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VGS SYNTHESIS PRIVATE LIMITED
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