2,4-Dimethoxyacetophenone

Synonym(s):Resacetophenone dimethyl ether

CAS NO.：829-20-9
Empirical Formula: C10H12O3
Molecular Weight: 180.2
MDL number: MFCD00008727
EINECS: 212-587-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is 2,4-Dimethoxyacetophenone?

Chemical properties

white to off-white crystalline powder

The Uses of 2,4-Dimethoxyacetophenone

2',4'-Dimethoxyacetophenone-d6 is an by-product in the synthesis of Paeonol-d3 (P133842). Paeonol-d3 is a labelled analogue of Paeonol (P133840), acting as a b-Secretase inhibitor an anti-apoptotic agent is used in the treatment of memory loss after ischemic stroke. Anti-inflammatory and analgesic.

Preparation

Obtained by reaction of dimethyl sulfate with resacetophenone in the presence of 10% aqueous sodium hydroxide (61%).

Definition

ChEBI: 2,4-Dimethoxyacetophenone is an aromatic ketone.

Properties of 2,4-Dimethoxyacetophenone

Melting point:	37-40 °C(lit.)
Boiling point:	288 °C(lit.)
Density	1.1272 (rough estimate)
refractive index	1.5430 (estimate)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Dichloromethane, Ethyl Acetate, Methanol
form	Crystalline Powder
color	White to off-white
Sensitive	Light Sensitive
BRN	511947
CAS DataBase Reference	829-20-9(CAS DataBase Reference)
NIST Chemistry Reference	2',4'-Dimethoxyacetophenone(829-20-9)

Safety information for 2,4-Dimethoxyacetophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.