2'',3'',5''-Triacetyl -azacytidine
- CAS NO.:10302-78-0
- Empirical Formula: C14H18N4O8
- Molecular Weight: 370.31
- MDL number: MFCD11113159
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-29 14:28:21
What is 2'',3'',5''-Triacetyl -azacytidine?
Description
5-
Chemical properties
White to off-white powder
The Uses of 2'',3'',5''-Triacetyl -azacytidine
5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]
in vivo
in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].
References
[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.
Properties of 2'',3'',5''-Triacetyl -azacytidine
Boiling point: | 497.3±55.0 °C(Predicted) |
Density | 1.60±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 3.06±0.20(Predicted) |
CAS DataBase Reference | 10302-78-0 |
Safety information for 2'',3'',5''-Triacetyl -azacytidine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'',3'',5''-Triacetyl -azacytidine
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