2,3-Dimethylbenzoic acid

Synonym(s):vic.-o-Xylylic acid

CAS NO.：603-79-2
Empirical Formula: C9H10O2
Molecular Weight: 150.17
MDL number: MFCD00002479
EINECS: 210-058-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-12 23:00:56

What is 2,3-Dimethylbenzoic acid?

Chemical properties

white to light yellow crystal powder

The Uses of 2,3-Dimethylbenzoic acid

2,3-Dimethylbenzoic Acid is used as a reagent in the synthesis of pyridyl benzamides as inhibitors for the kinetoplastid Trypanosoma brucei. 2,3-Dimethylbenzoic Acid is also used as a reagent in the synthesis of 2,3-Dihydro-1H-isoindole-4-carboxylic Acid (D450070) which is a reagent used in the synthesis of aminoalkylbenzoic acid derivatives for the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, neuropathic pain, neuropathological disorders and sleep disorders.

Definition

ChEBI: A dimethylbenzoic acid in which the two methyl groups are located at positions 2 and 3.

General Description

2,3-Dimethylbenzoic acid shows high binding affinity with antenna-specific odorant-binding protein of the alfalfa plant bug, Adelphocoris lineolatus.

Purification Methods

Crystallise the acid from EtOH. It is volatile in steam. The amide has m 156o (from H2O). [Beilstein 9 H 531, 9 III 2434, 9 IV 1797.]

Properties of 2,3-Dimethylbenzoic acid

Melting point:	144-146 °C (lit.)
Boiling point:	271.51°C (estimate)
Density	1.0937 (estimate)
refractive index	1.5188 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	pKa: 3.771(25°C)
form	powder to crystal
color	White to Almost white
BRN	971590
InChI	InChI=1S/C9H10O2/c1-6-4-3-5-8(7(6)2)9(10)11/h3-5H,1-2H3,(H,10,11)
CAS DataBase Reference	603-79-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 2,3-dimethyl-(603-79-2)

Safety information for 2,3-Dimethylbenzoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.