2-Trifluoromethylphenylboronic acid
- CAS NO.：1423-27-4
- Empirical Formula: C7H6BF3O2
- Molecular Weight: 189.93
- MDL number: MFCD00236059
- EINECS: 640-203-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 2-Trifluoromethylphenylboronic acid?
Chemical properties
white to light beige crystalline powder
The Uses of 2-Trifluoromethylphenylboronic acid
2-Trifluoromethylphenylboronic Acid is a reagent in the preparation of potent inhibitors of human uric acid transporter 1 (hURAT1).
The Uses of 2-Trifluoromethylphenylboronic acid
suzuki reaction
The Uses of 2-Trifluoromethylphenylboronic acid
2-(Trifluoromethyl)phenylboronic acid can be used as a reactant:
- In Suzuki-coupling reactions to prepare 2-trifluoromethyl aryl or heteroaryl derivatives.
- To synthesize 4-(2-trifluoromethyl)phenylpyrrolo[2,3-d]pyrimidine as a potential antagonist of corticotropin-releasing hormone.
- To prepare 2-nitro-6-(trifluoromethyl)phenylboronic acid by nitration reaction.
Properties of 2-Trifluoromethylphenylboronic acid
| Melting point: | 111-114 °C (lit.) |
| Boiling point: | 274.5±50.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | slightly sol. in Methanol |
| form | powder to crystal |
| pka | 8.11±0.58(Predicted) |
| color | White to Almost white |
| BRN | 2974465 |
| CAS DataBase Reference | 1423-27-4(CAS DataBase Reference) |
Safety information for 2-Trifluoromethylphenylboronic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Trifluoromethylphenylboronic acid
| InChIKey | JNSBEPKGFVENFS-UHFFFAOYSA-N |
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