2-Methyl-D-phenylalanine

Synonym(s):α-Me-D-Phe-OH;(R)-(+)-2-Amino-2-methyl-3-phenylpropionic acid

CAS NO.：17350-84-4
Empirical Formula: C10H13NO2
Molecular Weight: 179.22
MDL number: MFCD00153491
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 2-Methyl-D-phenylalanine?

Chemical properties

White powder

The Uses of 2-Methyl-D-phenylalanine

2-Methyl-D-phenylalanine is a derivative of D-Phenylalanine (P319410); the stereoisomer of L-Phenylalanine (P319415) used in the synthesis of Schaeffer’s acid analogs as important structures in tuberculostatic design. These analogs exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.

The Uses of 2-Methyl-D-phenylalanine

α-Methyl-D-phenylalanine is used to prepare hippuryl-α-methylphenylalanine and hippuryl-α-methylphenyllactic acid as substrates for carboxypeptidase A. It is also used in the synthesis of high affinity tachykinin NK2 receptor antagonists.

Properties of 2-Methyl-D-phenylalanine

Melting point:	277-279 °C(Solv: acetone (67-64-1))
Boiling point:	312.8±30.0 °C(Predicted)
Density	1.166±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	Powder
pka	2.25±0.10(Predicted)
color	White to pale yellow
BRN	5254151
CAS DataBase Reference	17350-84-4(CAS DataBase Reference)

Safety information for 2-Methyl-D-phenylalanine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.