2-methyl-1,3-thiazole-5-carboxylic acid

CAS NO.：40004-69-1
Empirical Formula: C5H5NO2S
Molecular Weight: 143.16
MDL number: MFCD01760300
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-17 21:30:02

What is 2-methyl-1,3-thiazole-5-carboxylic acid?

Synthesis

To a stirred solution of 2-methyl-thiazole-5-carboxylic acid ethyl ester (1.3 g, 8.0 mmol) in dioxane (12 mL) at room temperature was added NaOH (2N, 12 mL). After 1 h the reaction mixture was neutralized with HCl (IN, 12 mL), then filtered and the collected solid dried in vacuo to give 2-methyl-1,3-thiazole-5-carboxylic acid (758 mg, 70percent) as an off white solid.

Properties of 2-methyl-1,3-thiazole-5-carboxylic acid

Melting point:	209 °C(Solv: water (7732-18-5))
Boiling point:	301.2±15.0 °C(Predicted)
Density	1.418±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	3.78±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C5H5NO2S/c1-3-6-2-4(9-3)5(7)8/h2H,1H3,(H,7,8)

Safety information for 2-methyl-1,3-thiazole-5-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.