2-Methoxybenzonitrile

CAS NO.：6609-56-9
Empirical Formula: C8H7NO
Molecular Weight: 133.15
MDL number: MFCD00001783
EINECS: 229-559-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-24 19:19:26

What is 2-Methoxybenzonitrile?

Chemical properties

Colorless liquid

The Uses of 2-Methoxybenzonitrile

2-Methoxybenzonitrile was used in the synthesis of 5-(4′-methyl [1,1′-biphenyl]-2-yl)-1H-tetrazole.

Preparation

o-Anisidine with sodium nitrite to make a diazonium salt solution, add it to the lead cyanide solution, and then add benzene. Put the mixture for 10-15h and carry out steam distillation, separate the benzene layer from the distillate, dry it with calcium chloride, evaporate the benzene, and distill the residue under reduced pressure, collect 120-122.5°C (1.2kPa fraction) to get 2-Methoxybenzonitrile, yield 64.5-67.3%.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 109, 1955 DOI: 10.1021/ja01606a035
Synthesis, p. 641, 1992
Tetrahedron Letters, 32, p. 1007, 1991 DOI: 10.1016/S0040-4039(00)74473-X

General Description

Surface-enhanced Raman spectra study of 2-methoxybenzonitrile has been reported.

Properties of 2-Methoxybenzonitrile

Melting point:	24.5°C
Boiling point:	135 °C12 mm Hg(lit.)
Density	1.093 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5465(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
Water Solubility	Slightly soluble in water
form	Liquid
color	Clear colorless to pale yellow
BRN	2207134
InChI	InChI=1S/C8H7NO/c1-10-8-5-3-2-4-7(8)6-9/h2-5H,1H3
CAS DataBase Reference	6609-56-9(CAS DataBase Reference)
NIST Chemistry Reference	o-Methoxybenzonitrile(6609-56-9)

Safety information for 2-Methoxybenzonitrile

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.