2-Methoxybenzonitrile
- CAS NO.:6609-56-9
- Empirical Formula: C8H7NO
- Molecular Weight: 133.15
- MDL number: MFCD00001783
- EINECS: 229-559-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-22 20:27:16
What is 2-Methoxybenzonitrile?
Chemical properties
Colorless liquid
The Uses of 2-Methoxybenzonitrile
2-Methoxybenzonitrile was used in the synthesis of 5-(4′-methyl [1,1′-biphenyl]-2-yl)-1H-tetrazole.
Preparation
o-Anisidine with sodium nitrite to make a diazonium salt solution, add it to the lead cyanide solution, and then add benzene. Put the mixture for 10-15h and carry out steam distillation, separate the benzene layer from the distillate, dry it with calcium chloride, evaporate the benzene, and distill the residue under reduced pressure, collect 120-122.5°C (1.2kPa fraction) to get 2-Methoxybenzonitrile, yield 64.5-67.3%.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 109, 1955 DOI: 10.1021/ja01606a035
Synthesis, p. 641, 1992
Tetrahedron Letters, 32, p. 1007, 1991 DOI: 10.1016/S0040-4039(00)74473-X
General Description
Surface-enhanced Raman spectra study of 2-methoxybenzonitrile has been reported.
Properties of 2-Methoxybenzonitrile
Melting point: | 24.5°C |
Boiling point: | 135 °C12 mm Hg(lit.) |
Density | 1.093 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
Water Solubility | Slightly soluble in water |
form | Liquid |
color | Clear colorless to pale yellow |
BRN | 2207134 |
InChI | InChI=1S/C8H7NO/c1-10-8-5-3-2-4-7(8)6-9/h2-5H,1H3 |
CAS DataBase Reference | 6609-56-9(CAS DataBase Reference) |
NIST Chemistry Reference | o-Methoxybenzonitrile(6609-56-9) |
Safety information for 2-Methoxybenzonitrile
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methoxybenzonitrile
InChIKey | FSTPMFASNVISBU-UHFFFAOYSA-N |
SMILES | C(#N)C1=CC=CC=C1OC |
2-Methoxybenzonitrile manufacturer
Syn Finechem Laboratories Pvt Ltd.
Anami Organics
BASR Fine Chemicals Pvt. Ltd.
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