2-(1H-Imidazol-1-yl)ethanamine
- CAS NO.:5739-10-6
- Empirical Formula: C5H9N3
- Molecular Weight: 111.15
- MDL number: MFCD06798214
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-27 15:02:44
What is 2-(1H-Imidazol-1-yl)ethanamine?
The Uses of 2-(1H-Imidazol-1-yl)ethanamine
2-(1H-Imidazol-1-yl)ethanamine is an intermediate for the preparation of selective tumor inhibitor bis(nitroimidazolyl)alkanecarboxamide hypoxia.
Synthesis
Imidazole (8.10 g, 119 mmol), 2-chloroethylamine monohydrochloride (15.2 g, 131 mmol), tetrabutylammonium hydrogensulfate (1.62 g, 4.8 mmol), and sodium hydroxide (17.1 g, 428 mmol) were combined with 100 ml acetonitrile and heated under reflux for 21 h. The reaction mixture was cooled and filtered. The filtrate was concentrated to a pale yellow oil. Flash chromatography (silica gel, gradient elution of acetonitrile to 9:1 acetonitrile/NH4OH) afforded 4.52 g (34%) of 2-(1H-Imidazol-1-yl)ethanamine as a pale yellow oil.
Properties of 2-(1H-Imidazol-1-yl)ethanamine
Boiling point: | 283℃ |
Density | 1.15 |
Flash point: | 125℃ |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
pka | 7.51±0.10(Predicted) |
Safety information for 2-(1H-Imidazol-1-yl)ethanamine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(1H-Imidazol-1-yl)ethanamine
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
AKOS BBS-00004118
3-((4,5-DICHLOROIMIDAZOLYL)METHYL)-4-BROMO-2-METHYL-1-PHENYL-3-PYRAZOLIN-5-ONE
2-(4,5-DICHLOROIMIDAZOLYL)-N-(2-INDOL-3-YLETHYL)ETHANAMIDE
N-[(2-CHLOROBENZOYL)OXY]-2-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)ACETAMIDE
N1-(4-ISOPROPYLPHENYL)-2-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)ACETAMIDE
N'1-(2-CHLORO-6-FLUOROBENZYLIDENE)-2-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)ETHANOHYDRAZIDE
2-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)-N-HYDROXYACETAMIDE
N1-(3-CHLOROPHENYL)-2-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)ACETAMIDE
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