2'-Hydroxy-5'-methoxyacetophenone

CAS NO.：705-15-7
Empirical Formula: C9H10O3
Molecular Weight: 166.17
MDL number: MFCD00008731
EINECS: 211-882-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is 2'-Hydroxy-5'-methoxyacetophenone?

Chemical properties

yellow crystalline powder

The Uses of 2'-Hydroxy-5'-methoxyacetophenone

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.

Preparation

reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).

What are the applications of Application

2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.

Synthesis Reference(s)

Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380

General Description

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.

Properties of 2'-Hydroxy-5'-methoxyacetophenone

Melting point:	52 °C(lit.)
Boiling point:	254.38°C (rough estimate)
Density	1.1708 (rough estimate)
refractive index	1.5500 (estimate)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	10.65±0.18(Predicted)
form	Crystalline Powder
color	Yellow
Odor	Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity.
BRN	1239364
CAS DataBase Reference	705-15-7(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)

Safety information for 2'-Hydroxy-5'-methoxyacetophenone

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.