2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE
- CAS NO.:1641-17-4
- Empirical Formula: C15H14O3
- Molecular Weight: 242.27
- MDL number: MFCD00017172
- EINECS: 216-688-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 18:52:02
What is 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE?
Originator
Uvistat-L,Ward Blenkinsop,UK,1960
The Uses of 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE
sunscreen
The Uses of 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE
2-Hydroxy-4-methoxy-4'-methyl-benzophenone is an UV absorbing agent in sunscreen cosmetic creams, lotions, lipstieks, sun oils, etc.
Preparation
Preparation by Friedel–Crafts acylation of m-methoxy-phenol with p-toluoyl chloride,
in the presence of boron trichloride in benzene first at ?10°, then at reflux for 10 h under nitrogen (80%)
in the presence of titanium tetrachloride in benzene first at ?10°, then at reflux for 14 h under nitrogen (73%) or in chlorobenzene for 1 h at 120° (79%).
Definition
ChEBI: Mexenone is a member of benzophenones.
Manufacturing Process
p-Toluoyl chloride is the starting material. To this is added chlorobenzene and
1,3-dimethoxybenzene. The reaction mixture is cooled to 12°C in an ice bath
and aluminum chloride is added gradually, keeping the reaction below 30°C.
The reaction is then gradually heated to 115°C with the evolution of hydrogen
chloride gas. As the temperature increases, the reaction mixture becomes
thicker. At 105°C, dimethyl formamide is added slowly. The reaction is heated
at 115°C for a short time and is then poured into concentrated hydrochloric acid. The reaction mixture pours very easily and very cleanly. The acid
mixture is heated with steam to dissolve all the material which had not
hydrolyzed and the mixture is filtered. The red chlorobenzene layer is
separated and washed twice with hot water.
To the chlorobenzene solution is then added sodium hydroxide dissolved in
water and the chlorobenzene is removed by a steam distillation. After all of
the chlorobenzene is removed, the precipitate which forms during the
distillation is removed by filtration and discarded. The solution is cooled and
acidified with hydrochloric acid, precipitating a tan solid. This is removed by
filtration and washed acid-free. It is then treated with sodium bicarbonate
solution to remove any acid present and is then washed with water to remove
all traces of bicarbonate. After drying approximately a 75% yield of mexenone
is obtained.
Therapeutic Function
Sunscreen agent
Contact allergens
BZP-10 is exceptionally positive in ketoprofen-photosensitive patients.
Properties of 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE
Melting point: | 99-102°C |
Boiling point: | 345.09°C (rough estimate) |
Density | 1.1515 (rough estimate) |
refractive index | 1.5570 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
form | Solid |
pka | 7.35±0.35(Predicted) |
color | Pale Yellow to Light Yellow |
Merck | 14,6167 |
BRN | 1972646 |
CAS DataBase Reference | 1641-17-4(CAS DataBase Reference) |
Safety information for 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE
Abamectin manufacturer
Sri Neelima Laboratories
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